Abkürzungen
AWMF – Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften e.V.
BMS – Bristol Myers Squibb
CIMP – CpG island methylator phenotype
CpG – Cytosin-phosphatidyl-Guanin
dMMR – Deficient Mismatch Repair
DNA – Desoxyribonukleinsäure
EC – Endometriumkarzinom
EMA – European Medicines Agency
EMAST – Elevated Microsatellite Alterations at Selected Tetranucleotide Repeats
FAP – Familiäres Adenomatöses Polyposis coli
GSK – Glaxo Smith Kline
HNPCC – Hereditary Non-Polyposis Colorectal Cancer
IHC – Immunohistochemistry
ICI – Immun-Checkpoint-Inhibitoren
KRK – Kolorektalkarzinom
LS – Lynch-Syndrom
MLH1 – MutL homolog 1
MMR – Mismatch-Repair
MSD – MSD Sharp & Dohme
MSH2 – MutS homolog 2
MSH3 – MutS homolog 3
MSH6 – MutS homolog 6
MSI – Mikrosatelliteninstabilität
MYCL1 – L-myc-1 proto-oncogene protein
NCCN – National Comprehensive Cancer Network
NGS – Next Generation Sequencing
NICE – National Institute for Health and Care Excellence
PCR – Polymerase-Kettenreaktion
PD-L1 – Programmed Cell Death Ligand 1
PMS2 – Postmeiotic Segregation Increased 2
POLE – DNA Polymerase Epsilon, Catalytic Subunit
QuIP – Qualitätssicherungs-Initiative Pathologie GmbH
RAS – Rat Sarcoma
TILS – Tumorinfiltrierende Lymphozyten
WHO – World Health Organization
WT – Wildtyp